Abstract

Threat of antibiotic resistant pathogens has become serious global public health issue, leading to emergence of different brands of antibiotics from different pharmaceuticals. This study was aimed at comparing and evaluating different brands of antibiotics on pathogenic bacteria isolated from domestic dogs in  some environmentally challenged communities in Eleme. A convenience sampling technique was used to aseptically collect fifty (50) samples from the mouth and nostrils of domestic dogs. Culture, isolation and identification of organisms were explored using standard microbiological techniques. Different brands of antibiotic sensitivity discs were purchased from pharmaceutical retail outlets and sensitivity testing performed as described by the Clinical Laboratory Standard Institute (CLSI). Bacteria isolated and identified and frquency were Escherichia coli (21%), Klebsiella spp (20%) and Proteus spp (7%), Bacillus spp (2%), Staphylococcus aureus (10%) and unicellular fungus, Candida albicans (8%). Three brands of the different antibiotics used were statistically significant at P>0.05, Abtek biological limited (71.76(32%), Cetech Diagnostic (72.14(33%), and Oxoid standard single disc (73.06(33%) while locally manufactured disc 1 (4.93 (2%) and disc 2 (9.86(4%) were not statistically significant. There was significant difference between Abtek biological limited, Cetech Diagnostic and Oxoid standard single disc (P<0.05). There was no significant difference between locally made discs in comparison to the other three brands. The findings revealed that, common pathogens are becoming increasingly resistant to some locally manufactured antibiotics. Hence there is urgent need to improve various pharmaceutical stewardship which would in-turn improve on the potency of products manufactured.